Selected Recent Publications



  • 1. Davis, J., Xu, F., Deane, R., Romanov, G., Previti, M., Zeigler, K., Zlokovic, B.V., and Van Nostrand, W.E. Early-onset and robust cerebral microvascular accumulation of amyloid ß-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid ß-protein precursor. Journal of Biological Chemistry 279:20296-20306 (2004).
  • 2. Miao, J., Xu, F., Otte-Höller, I., Verbeek, M.M., Davis, J., and Van Nostrand, W.E. Cerebral microvascular Aß deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant AßPP. American Journal of Pathology 167:505-515 (2005).
  • 3. Miao, J., Vitek, M.P., Xu, F., Previti, M.L., Davis, J., and Van Nostrand, W.E. Reducing cerebral microvascular amyloid ß protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice. Journal of Neuroscience 25:6271-6277 (2005).
  • 4. Xu, F., Davis, J., Miao, J., Previti, M.L., Romanov, G., Zeigler, K., and Van Nostrand, W.E. Protease nexin-2/amyloid ß-protein precursor limits cerebral thrombosis. Proceedings of the National Academy of Sciences USA 102:18135-18140 (2005).
  • 5. Davis, J., Xu, F., Previti, M., Romanov, G., Zeigler, K., and Van Nostrand, W.E. Deficient cerebral clearance of vasculotropic mutant Dutch/Iowa double mutant Aß in human AßPP transgenic mice. Neurobiology of Aging 26:946-954 (2006).
  • 6. Previti, M.L., Zhang, W., and Van Nostrand W.E. Dexamethasone diminishes the pro-inflammatory and cytotoxic effects of amyloid ß-protein in cerebrovascular smooth muscle cells. Journal of Neuroinflammation 3:18(2006).
  • 7. Hoos, M.D., Ahmed, M., Smith, S.O., and Van Nostrand, W.E. Inhibition of familial cerebral amyloid angiopathy mutant amyloid ß-protein fibril assembly by myelin basic protein. Journal of Biological Chemistry 282:9952-9961 (2007). 
  • 8. Xu, F., Grande, A.M., Robinson, J.K., Previti, M.L., Davis, J., and Van Nostrand, W.E. Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant AßPP transgenic mice. Neuroscience 146:98-107 (2007).
  • 9. Fan, R., Xu, F., Previti, M.L., Davis, J., Grande, A.M., Robinson, J.K., and Van Nostrand, W.E. Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. Journal of Neuroscience 27:3057-3063 (2007).
  • 10. Xu, F., Previti, M.L., and Van Nostrand, W.E. Increased severity of hemorrhage in transgenic mice expressing cerebral protease nexin-2/amyloid ß-protein precursor. Stroke (2007).
  • 11. Wilcock, D.M., Lewis, M.R., Van Nostrand, W.E., Davis, J., Previti, M.L., Gharkholonareh, N., Vitek, M.P., and Colton, C.A. Progression of amyloid pathology to Alzheimer's pathology in an APP transgenic mouse model by removal of NOS2. Journal of Neuroscience 28:1537-1545 (2008).
  • 12. Xu, F., Vitek, M.P., Colton, C.A., Previti, M.P., Gharkholonarehe, N., Davis, J., and Van Nostrand, W.E. Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice. Journal of Neuroscience 28:5312-5320 (2008).
  • 13. Van Vickle, G.D., Esh, C.L., Daugs, I.D., Kokjohn, T.A., Kalback, W.M., Patton, R.L., Leuhrs, D.C., Walker, D.G., Lue, L.F., Beach, T.G., Davis, J., Van Nostrand, W.E., Castano, E.M., Roher, A.E.  Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy.  American Journal of Pathology 173920:483-93, (2008).


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