CURRENT RESEARCH

 

ALLERGY/IMMUNOLOGY/PULMONOLOGY

Impact of Patient and Physician Education in Morbidity in Children Suffering from Asthma.  American Lung Association of Nassau-Suffolk.

National Airway Clearance Registry: Airway Clearance in Mucus Hypersecretion with the VEST system.  Advanced Respiratory, Inc.

A randomized 2 period multicenter double blind parallel group study comparing the effects of two doses of montelukast granules and placebo in the treatment of respiratory symptoms associated with respiratory syncytial virus induced bronchiolitis in children aged 6 to 18 months.  Merck.

Partnership with community health care centers: making a difference in asthma care.  American Lung Association of Nassau-Suffolk.

The use of formula fortified with docosahexaenoic acid (DHA) in infants with cystic fibrosis (CF).  University of Massachusetts

Implications of Sleep and Fatigue in Pediatric HIV.  NIH RFA.
 
A Phase 3, Double-Blind, Multi-center, Randomized, Placebo-Controlled Trial withAztreonam Lysinate for Inhalation in Cystic Fibrosis Patients with Pulmonary P. aeruginosa Requiring Frequent Antibiotics.  Corus Pharma

BEHAVIORAL / DEVELOPMENTAL

Dr. Janet Fischel
Dr. Fischel is principal investigator on one of eight national longitudinal Quality Research Center consortium grants from the Department of Heath and Human Services, Administration for Children and Families (DHHS/ACF). 

Each of the grants is focused on improving readiness for academic success for children from low-income families.  Dr. Fischel’s project is entitled Evidence-based Emergent Literacy Approaches for Head Start.  

ENDOCRINOLOGY

ECRIP Fellowship program
Effect of Insulin & Leucine on Protein synthesis in T1DM

TRO
Effect of thiazolidinediones on coarse of T1DM

Pfizer
KIGS: International Growth Study

Genentech:
Post marketing Study of Growth Hormone

Tercica, Inc:
Use of IGF-1 in Cystic Fibrosis

 

GASTROENTEROLOGY

Dr. Anupama Chawla

Effect of Total caloric Intake on Parenteral Nutrition Associated Cholestasis in Low Birth Weight Infants.

Correlation of Autoimmune Thyroiditis and Celiac Disease.

Reliabilty of infant length measurement: A comparison of tape and length board

Drinkable Aloe Vera Gel(DAVG) for the treatment of Irritable Bowel Syndrome in Children.

 

GENERAL PEDIATRICS

Dr. Leslie Quinn and Dr. Rachel Boykan
Child Abuse Study – TEACH: Tool to educate on assessment of childhood harm

Dr. Susan Guralnick
Medical Home Grant

Dr. Susan Mangiameli and Dr. Latha Chandran
Resident Education Project in Otitis Media

Dr. Maribeth Chitkara
Lumbar Punctures Performed by Pediatric Residents: Implementation and Evaluation of a Teaching Curriculum and Training Program

Dr. Latha Chandran and Dr. Carolyn Milana
Does Meditation and Infant Massage Affect Maternal Anxiety and Infant Health Outcome.  GCRC funded and Departmental Intramural funded.

 

GENETICS

Dr. Patricia Galvin-Parton

NYS-DOH                                         

NYS-DOH/HRSA                             
Multicenter project – Factors Affecting Utilization of Public Health Facilities for Genetic and Prenatal Services in Underserved Areas of New York State

NYMAC/NYS-DOH/HRSA              
Develop Diagnostic and Treatment Protocols and a System for Long-term Follow-up Care for Metabolic Diseases Incorporated into the Expanded NYS Newborn Screening Program

Studying the Genetics involved in BPD

Development Of Cut-Off Values And Protocol For Detecting Infants With MCAD Through A Newborn Screening Program – Multicenter Project

Genotype-Phenotype Correlations In PKU And The Impact On Treatment Protocols

Do Premature Infants Who Are Supplemented With Carnitine Because Of A Positive NBS For Carnitine Deficiency Do Better In Terms Of Weight Gain Or Decreased Apnea Than Similar Premature Infants Who Are Screen Normal And Therefore Not Supplemented With Carnitine.

Dr. David Tegay

National Alliance for Autism Research

Pediatric LRP Award
National Institutes of Health

K23; Mentored Patient Oriented Career Development Award
                                   
Genomic Copy Number Variation in Autism

Genomic Variation in Developmental Disability

Williams Syndrome Cognitive Phenotype: From Genes to Behavior

Coldspring Harbor Projects:
Studying the Genetic Basis of Floating-Harbor Syndrome and Toriello-Carey Syndrome

 

HEMATOLOGY / ONCOLOGY

In addition to clinical activities, the Division is an active participant in COG (Children’s Oncology Group) clinical trials, has primary and collaborative laboratory research activities investigating tumor cell-signaling pathways and gene abnormalities, and investigator initiated clinical studies regarding cancer survivorship issues. 

Dr. Robert Parker

COG grant
 
USB SOM TRO:  Mitochondrial DNA mutations in survivors of childhood cancer

Dr. Edward Chan

K30 Clinical Research Scholarship Fellowship application:  Ras and Ron oncogene signaling in head and neck cancer

INFECTIOUS DISEASES

Dr. Sharon Nachman

NIH - Adolescent Master Protocol (AMP) 

NIH - Surveillance Monitoring of Antiretroviral Treatment Toxicities      

NIH - Psychiatric Co-Morbidity in Children with HIV (NIMH)                    

NIH - International Maternal Pediatric AIDS Clinical Trial (IMPACT)                

National Institutes of Child Health and Development       
Pediatric AIDS Clinical Trials Group                                             

National Institutes of Health                                                 
Adolescent Treatment Network (ATN)                               

Health Resources and Services Administration               
Suffolk Project for AIDS Resource Coordination             

National Institute of Mental Health                                      
Psychiatric Co-Morbidity in Children with HIV                  

Ryan White C.A.R.E. Act – Title I                                       
United Way of Long Island                                                  
Psychosocial Support Services

Ryan White C.A.R.E. Act – Title I                                       
United Way of Long Island                                                  
People of Color – Treatment Adherence
                                                                                                                                   
Ryan White C.A.R.E. Act – Title I                                       
United Way of Long Island                                                  
Mental Health – People of Color
                                                                                                                                   
Ryan White C.A.R.E. Act – Title I                                       
United Way of Long Island                                                  
Nutrition

New York State Department of Health                                           
AIDS Institute                                                                                    
Centers of Excellence in Pediatric Care                                                                                                   

Dr. Lucy Pontrelli

National Institutes of Child Health and Development       
Pediatric AIDS Clinical Trials Group                                             

Ryan White C.A.R.E. Act – Title I                                       
United Way of Long Island                                                  
Psychosocial Support Services

Pharmacia & Upjohn                                                                                                           
Linezolid: Ventricular Fluid & Plasma Levels in Pediatric Patients Receiving Multiple Doses (10mg/kg) of Linezoid Three Times Daily

Dr. Divna Nikolic-Djokic
National Institutes of Child Health and Development       
Pediatric AIDS Clinical Trials Group                                             

Health Resources and Services Administration               
Suffolk Project for AIDS Resource Coordination             

New York State Department of Health
AIDS Institute
Centers of Excellence in Pediatric Care
Ryan White C.A.R.E. Act – Title I
United Way of Long Island
Mental Health – People of Color

Dr. Denise Dixon

1 RO1 HL079526-01    
NIH/NHLBI/NIMH
Implications of Sleep Problems and Fatigue in Pediatric HIV

1 RO3 MH064906-01A2                             
Originally funded by NIH/NIMH/NCMHHD; currently funded by Department of Pediatrics
CBSM, Psychological & Physical Health In HIV+ Children

2U01 AI 25883-14                           
NIH/NIAID
New Jersey Pediatric AIDS Clinical Trials Consortium (UMDNJ, NJMS)
Sub-study: Adolescent Treatment Readiness Dixon (PI)

DB2 0104 2                                                                          
Christopher Reeve Paralysis Foundation (CRPF)
Sympathetic Nervous System (SNS) Dysregulation and Diminished Cellular Immunity in Spinal Cord Injury (SCI)

3 SCRF 2161                                   
Spinal Cord Research Foundation (SCRF)
Factors that Contribute to Infections during SCI Rehabilitation

“Implications of Sleep Problems and Fatigue in Pediatric HIV” (Competitive Renewal; NIH/NHLBI/NIMH)

MOLECULAR / NEUROBIOLOGY

Marian Evinger, Ph.D.
Nicotine-Mediated Regulation of Adrenergic Gene Expression
This project tests the hypothesis that a previously uncharacterized nuclear protein coordinately establishes control of PNMT gene expression in response to nicotinic stimuli.  The goals of this project are to identify and isolate cDNAs for transacting proteins that mediate responsiveness to nicotinic stimuli.  Structural and functional attributes of the the PNMT nicotine response element binding protein will be characterized.
Principal Investigator:  Marian J. Evinger, Ph.D.
Agency: Philip Morris USA and Philip Morris International.

Molecular Profile of Developmental Factors in Medulloblastoma 
The objective of this project is to define a molecular profile of transcription factors useful for differential diagnosis of medulloblastoma .  Quantitative real time PCR is employed to assess expression of candidate genes in human medulloblastoma tumors and cell lines.  Medulloblastoma-specific gene expression is further delineated by DNA microarray analyses of tumor and normal cerebellar RNAs. 
Principal Investigator:  Marian J. Evinger, Ph.D. (Co-Investigator, R. Seidman, M.D,)
Agency: Pediatric Oncology Targeted Research Opportunity, Stony Brook University School of Medicine

Nicotinic Regulation of Neural Gene Expression
This project delineates the mechanism of transcriptional activation by the Nicotine Response Element Binding Protein, ascertains intracellular signaling pathways, and examines the transcriptional profile of nicotinic stimulation of neural gene expression profiles.
Principal Investigator: Marian J. Evinger, Ph.D.
Agency: Philip Morris USA and Philip Morris International
Dates:  07/01/06- 06/30/09
Amount: $997,999

 

NEONATOLOGY

Dr. Joseph DeCristofaro

NIH & PGS
Wireless Apnea Monitor     

Dr. Avinash Chander

NIH-NHLBI
Lung Surfactant Secretion and Membrane Fusion NHLBI          
                                   

NEPHROLOGY

Dr. Dilys Whyte and Dr. Ivy Boydstun

NIH
FSGS Clinical Trial

NIH
TGF-Beta and the Profession of Renal Disease

 

Department of Pediatrics

Health Sciences Center
Stony Brook University Medical Center
Stony Brook, New York 11794-8111
631-444-2700
631-444-KIDS appointments