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Division of Neonatology

Recent Research/Publications

 

Intramural grants are offered to new faculty by both the Department of Pediatrics and Stony Brook University to help underwrite research by new faculty.  Our division prides itself on maintaining a collegial atmosphere and a supportive environment. 

The division has two major basic science laboratories equipped for animal pulmonary function testing, animal care facilities and well-trained, superb technicians.  We also maintain a neonatal biophysical acclerometer, contributing to our knowledge of the interplay between physics and biology.  Our residents and fellows actively contribute and assist junior and senior faculty in both clinical and basic science research projects, maintaining constant academic productivity. 

For clinical researchers, our collaboration with the Regional Perinatal Center and School of Public Health gives us access to a wealth of data on treatments and newborn outcomes.  We maintain a database of low birthweight patients and benchmark our quality of care with peer institutions.  Educational tracks aimed at obtaining a Master’s Degree in Public Health are available for both faculty and fellows. 
           
The Neonatal Intensive Care Unit at Stony Brook University Medical Center is noted for its contributions to the field of neonatology.  Our faculty members have pioneered the understanding of how certain genetic defects in utero cause problems in the organ systems of preterm infants.   Our division has contributed to our understanding of surfactant proteins and lung biology as well as created a public health infrastructure for prevention of respiratory tract infections in discharged infants.  Our clinical research group is known for discovering the effect of common maternal conditions such as chorioamnionitis and magnesium tocolysis on the clinical course of the infant. 

Larson, Janet E., Cohen J.C. Developmental paradigm for early features of cystic fibrosis. Pediatr Pulmonol. 2005 Nov;40(5):371-7. Invited Review.

Larson, Janet E., Cohen J.C. Improvement of Pulmonary Hypoplasia Associated With Congenital Diaphragmatic Hernia by In Utero CFTR Gene Therapy, Am J Physiol Lung Cell Mol Physiol. 2006 Feb 10.

Cohen, J.C.  and Larson, J.E. 2006 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Dependent Cytoskeletal Tension during Lung Organogenesis,  Dev. Dynamics, in press.

Broussard, D., Larson, J.E., Lundblad, L.K.A., Bates, J.H.T., and Cohen, J. C.  2006 Developmental changes in respiratory mechanics in the neonatal rat, Exp.  Lung Res.  In press.

Arita, Y, S.H. Harkness, J.A. Kazzaz, H. Koo, A. Joseph, J.A. Melendez, J.M. Davis, A. Chander, and Y. Li. Mitochondrial localization of catalase provides optimal protection from H2O2-induced cell death in lung epithelial cells. Am. J. Physiol. Lung Cell Physiol. 290: L978-86, 2006.

Smth-Kirwin, S, Bhandari, V,  DiMatteo, D, Barone, C, Johnson, L, Paul, S, Chander, A, Hassink, SG, and Funanage, V. Leptin enhances lung maturity in fetal rats. Pediatric Research.  In press.

Chander, A., D.G. Naidu, and X.-L. Chen. A ten-residue domain (Y11-A20) in the NH2-terminus modulates membrane association of annexin A7. Biochim. Biophys. Acta.  In press.

Sarkar S, Bhagat I, DeCristofaro JD, Wiswell TE and Spitzer AR. A study of the role of multiple site blood cultures in the evaluation of neonatal sepsis. J Perinatol. 26:18-22, 2006.

Verma RP, Chandra S, Niwas R, Komaroff E. Risk factors and clinical outcomes of pulmonary interstitial emphysema in extremely low birth weight infants.
J Perinatol. 2006 Mar;26(3):197-200.

Cohen, J.C. and Larson, J.E. CFTR-dependent Lung Organogenesis: Molecular Mechanism, European CF Conference April, 2006.

Moulton, K., Cohen, J.C., and Larson, J.E. Transient In Utero Knockout of CFTR Results in a Disruption of Organogenesis and Intestinal Epithelial Differentiation in Sprague-Dawley Rats,  Eastern Soc. Ped. Res., 2006

Gupta, S., Kileen, E. Larson, J.E. Cohen, J.C. Effect of nicotine on smooth muscle contraction related proteins during lung and intestine organogenesis.  Aspen Mead Johnson Neonatology Conference, May 2006.

Verma RP, Kaplan C, Komaroff E. Chorioamnionitis is not a risk factor for death in ELBW infants. Platform presentation, Eastern Society for Pediatric Research , CT, 2005.

Verma RP, Ogburn P, Kaplan C, Komaroff E. High dose MgSO4 tocolysis may contribute to death in ELBW infants. Poster presentation. Eastern Society for Pediatric Research , CT, 2005.
Chander A, Naidu, DG, and Chen, X-L. Deletions in the N-terminus affect annexin A7 characteristics including binding to lamellar bodies: Implications in surfactant secretion. Presented at Experimental Biology meeting 2005.

Chander, A., and D. Callender. Dedifferentiated type II cells show decreased TLR4 and increased RTI40 expression: Implication in alveolar epithelial response to gram-negative bacteria. Presented at the annual meeting of Experimental Biology 2006, San Francisco, CA, March 31 – April 5, 2006. FASEB J. 20: A213, 2006.

Chander, A., D.G. Naidu, and X-L Chen. Lamellar body fusion for surfactant secretion: Deletion of the 10-20 domain in the N-terminus decreases fusion activity of annexin A7. Presented at the annual meeting of Experimental Biology 2006, San Francisco, CA, March 31 – April 5, 2006. FASEB J. 20: A1439, 2006.  

Barber N, Chen J, and DeCristofaro JD. Hypothermia and Re-Warming in Extremely Low Birth Weight Infants and the Subsequent Clinical Consequences. Pediatric Res Abs 2006.   ESPR

Nimavat D, DeCristofaro JD, Chen JJ, Haque Z, Katz S, DeMeglio D, and Mao W, Effect of Supine and Prone Sleep Positions in Apnea of Prematurity.   ESPR

Nimavat D, DeCristofaro JD, Chen JJ, Haque Z, Katz S, DeMeglio D, and Mao W, Effect of Supine and Prone Sleep Positions in Apnea of Prematurity. Pediatric Res Abs 2006.

Moulton, K., Cohen, J.C., and Larson, J.E. The Effects of Transient In Utero Knockout (TIUKO) antisense CFTR treatment on intestinal development. Ped. Res., May 2006.

Gill D. and Larson J.  Function of CFTR Protein: Developmental Role  Bush A, Alton EWFW, Davies, JC, Griesenbach U, Jaff A (eds): Cystic Fibrosis in the 21st Century.  Prog Respir Res.  Basel, Karger, 2006 vol 34, pp54-60. 

Shah SI. Pancakes and Medical Statistics. Acad Med 2005 80: 452-454.

Shah S, Mally P, Hendricks-Munoz K. The Relationship of Endotracheal (ET) Tube Length and Pressure for Sustained Tidal Volume in a Compliant Lung Model. Proceedings of the American Thoracic Society 2005, Vol. 2. p A490. 

Shah SI, Caprio M, Strauss S.  et al. Management of a Full Term Infant with Hemolytic Disease of the Newborn due to Anti-Rh17 Antibodies with a Mother of the D- - phenotype. Amer. Journ. Hematol. 80(1) 2005. pgs. 88-89.

Amodio J, Biskup D, Rivera R, Shah SI, Fefferman, N.  Tubercular Splenic Abscess in a Neonate with Thrombocytopenia. Ped. Radiol.(2005) 35:887-890.

Shah SI. A 1920 Doctor in the Year 2000. Pat. Educ. Coun. 2006, (60) pg.100-101.

Shah SI, Mally P, Hendricks-Munoz K. Estimating Peak Inspiratory Pressure to Compensate for Endotracheal Tube Length at Neonatal Ventilation Settings in SIMV. Can. Jour. Resp. Therapy. Spring 2006 pg 34-38.

Shah SI, Caprio M, Hendricks-Munoz, K. A Computer-Based, Multivariate, Economic Analysis of Neonatal-Intensive-Care-Unit-Based Influenza Vaccine Administration to Parents in a Hospitalist Setting. Jour. Hosp. Med. 2006. Vol 1. (Suppl. 2) pg 25.

Shah SI, Caprio M, Hendricks-Munoz, K. Administration of Inactivated Trivalent Influenza Vaccine (TIV) to Parents of High-Risk Infants in the Neonatal Intensive Care Unit (NICU): A Novel Strategy to Increase Vaccination Rates. Jour. Hosp. Med. 2006. Vol 1. (Suppl. 2) pg 47.

Sridhar S , Chawla A.TPN associated Cholestasis in Children.  Textbook of Pediatric Gastroenterology Hepatology and Nutrition by  Dr Suraj Gupte 2006

Sridhar S , Baumgart S. Water Metabolism in newborn infants. Neonatal Nutrition and Metabolism 2nd Edition; 0ctober 2005 by William Hayes, Patti Thureen

 

Division of Neonatology

Department of Pediatrics
T11 060 Health Sciences Center
Stony Brook University Medical Center
Stony Brook, New York  11794-8111
631-444-7653