Stony Brook University Medical Center: Department of Pediatrics

Pediatrics - Subspecialty Services

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Infectious Diseases

Recent Research/Publications

Recent Grants/Publications:

National Institutes of Child Health and Development, Pediatric AIDS Clinical Trials Group

National Institutes of Health, Adolescent Treatment Network (ATN)

Health Resources and Services Administration, Suffolk Project for AIDS Resource Coordination

National Institute of Mental Health, Psychiatric Co-Morbidity in Children with HIV
Ryan White C.A.R.E. Act – Title I, United Way of Long Island, Psychosocial Support Services

Ryan White C.A.R.E. Act – Title I, United Way of Long Island , People of Color – Treatment Adherence

Ryan White C.A.R.E. Act – Title I, United Way of Long Island , Mental Health – People of Color

Ryan White C.A.R.E. Act – Title I, United Way of Long Island , Nutrition

New York State Department of Health, AIDS Institute, Centers of Excellence in Pediatric Care

National Institutes of Child Health and Development, Pediatric AIDS Clinical Trials Group

Ryan White C.A.R.E. Act – Title I, United Way of Long Island , Psychosocial Support Services

Pharmacia & Upjohn, Linezolid: Ventricular Fluid & Plasma Levels in Pediatric Patients Receiving Multiple Doses (10mg/kg) of Linezoid Three Times Daily

National Institutes of Child Health and Development, Pediatric AIDS Clinical Trials Group

Health Resources and Services Administration, Suffolk Project for AIDS Resource Coordination

New York State Department of Health, AIDS Institute, Centers of Excellence in Pediatric Care

Ryan White C.A.R.E. Act – Title I, United Way of Long Island     , Mental Health – People of Color

NIH/NHLBI/NIMH, Implications of Sleep Problems and Fatigue in Pediatric HIV

Originally funded by NIH/NIMH/NCMHHD; currently funded by Department of Pediatrics
CBSM, Psychological & Physical Health In HIV+ Children

NIH/NIAID, New Jersey Pediatric AIDS Clinical Trials Consortium (UMDNJ, NJMS), Sub-study: Adolescent Treatment Readiness Dixon (PI)

Christopher Reeve Paralysis Foundation (CRPF), Sympathetic Nervous System (SNS) Dysregulation and Diminished Cellular Immunity in Spinal Cord Injury (SCI)

Spinal Cord Research Foundation (SCRF), Factors that Contribute to Infections during SCI Rehabilitation

A double-blind, randomized, controlled study to evaluate the immunogenicity and safety of GlaxoSmithKline Biologicals’ herpes simplex candidate vaccine (gD2‑AS04) in healthy HSV seronegative and seropositive female subjects aged 10 – 17 years”

Adherence Patterns Among Chronically Ill Children” Investigator Initiated study

A multicenter, open-label, single-arm, two-step study to evaluate the safety and single-dose pharmacokinetics of famciclovir and multiple-dose safety after administration of famciclovir oral pediatric formulation to children 1 to 12 years of age with herpes simplex infection” Protocol CFAM810B2303 Part A, B

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of MEDI-524, a Humanized Enhanced Potency Monoclonal Antibody Against Respiratory Syncytial Virus (RSV), in Children with Hemodynamically Significant Congenital Heart Disease” Protocol # MI-CP124

A Phase I, Randomized, Placebo-Controlled, Double-Blind Trial to Evaluate the Safety and Immunogenicity of FluMistâ a Live, Intranasal Influenza Virus Vaccine vs. Placebo in Immunocompromised Children Ages 5 through 17 Years of Age”, Protocol MI-CP114

A Phase III, Randomized, Multinational Study, Double-Blinded for the Immunogenicity and Consistency Evaluation of 3 Hib-MenCY-TT Vaccine Lots and Single-Blinded and Controlled for the Evaluation of Safety and Immunogenicty of GSK Biologicals’ Haemophilus Influenzae type B and Neisseria Meningitidis Serogroups C and Y-tetanus Toxoid Conjugate Vaccine Combined (Hib-MenCY-TT) Compared to Monovalent Hib Vaccine in Healthy Infants at 2, 4, 6, and 12 to 15 Months of Age” Protocol 103813 (Hib-MenCY-TT-009 Primary Study), Protocol 105067 (Hib-MenCY-TT-010 Booster Study).

Safety and Efficacy of Varicella Zoster Immune Globulin (Human) (VariZIG™) in Patients At-Risk of Varicella Infection” Protocol # VZ-009

D.M. Gaughan, M.D. Hughes, J.M. Oleske, K. Malee, S. Nachman, for the PACTG 219C Team. Psychiatric hospitalizations among children and youths with human immunodeficiency virus infection. Pediatrics 2004;113(6):e544-e551.

J. Hitti, L.M. Frenkel, A.M. Stek, S.A. Nachman, D. Baker, A. Gonzalez-Garcia, A. Provisor, E.M. Thorpe, M.E. Paul, M. Foca, J. Gandia, S. Huang, L.J. Wei, L.M. Stevens, D.H. Watts, J. McNamara, for the PACTG 1022 Study Team. Maternal toxicity with continuous nevirapine in pregnancy: Results from PACTG 1022. J Acquir Immune Defic Syndr 2004;36(3):772-776.

C.V. Fletcher, R. Yogev, S.A. Nachman, A. Wiznia, S. Pelton, K. McIntosh, and K. Stanley. Pharmacokinetic characteristics of ritonavir, zidovudine, lamivudine, and stavudine in children with human immunodeficiency virus infection. Pharmacotherapy 2004;24(4):453-9.

R.J. Jeremy, S. Kim, M. Nozyce, S. Nachman, K. McIntosh, S.I. Pelton, R. Yogev, A. Wiznia, G.M. Johnson, P. Krogstad, and K. Stanley for the Pediatric AIDS Clinical Trials Group (PACTG) 338 & 377 Study Teams. Neuropsychological functioning and viral load in stable antiretroviral therapy-experienced HIV-infected children. Pediatrics 2005;115(2):380-387.

S. Nachman, P. Gona, W. Dankner, A. Weinberg, R. Yogev, A. Gershon, M. Rathore, J. S. Read, S. Huang, C. Elgie, K. Hudgens, and W. Hughes. The Rate of Serious Bacterial Infections Among HIV-Infected Children with Immune Reconstitution Who Have Discontinued Opportunistic Infection Prophylaxis. Pediatrics 2005;115:488-494.

S.A. Nachman, J.C. Lindsey, J. Moye, K.E. Stanley, G.M. Johnson, P.A. Krogstad, and A.A. Wiznia for the PACTG 377 Study Team. Growth of human immunodeficiency virus-infected children receiving highly active antiretroviral therapy. J Pediatr Infect Dis 2005;24(4):352-357.

S.I. Pelton, K. Stanley, R. Yogev, C.V. Fletcher, K. McIntosh, A. Wiznia, and S. Nachman for the PACTG 338 Study Team. Switch from ritonavir to indinavir combination therapy for HIV-infected children. Clin Infect Dis 2005;40:1181-7.

H.M. Rosenblatt, K.E. Stanley, L.Y.Song, G.M. Johnson, A.A. Wiznia, S.A. Nachman, P.A. Krogstad and the PACTG 377 Study Team. Immunologic response to combination therapy in children with clinically stable HIV infection. J Infect Dis 2005;192:445-455.

S.K. Gupta, J.A. Eustace, J.A. Winston, I.I. Boydstun, T.S. Ahuja, R.A. Rodriguez, K.T. Tashima, M. Roland, N. Franceschini, F.J. Palella, Jr., J.L. Lennox, P.E. Klotman, S.A. Nachman, S.D. Hall, L.A. Szczech. Guidelines for the management of chronic kidney disease in HIV-infected patients: Recommendations of the HIV Medical Association of the Infectious Diseases Society of America. Clin Infect Dis 2005;40(11):1559-85.

J.Y. Ang, S. Ray-Mazumder, S.A. Nachman, C. Rongkavilt, B.I. Asmar and C.L. Ren. Use of complementary and alternative medicine by parents of pediatric HIV, pediatric asthma and well child patients. South Med J 2005; 98(9):869-75.

L.J. Grando, D.C. Machado, S. Spitzer, S. Nachman, F. Ferguson, B. Berentsen, L.S. Yurgel. Viral coinfection in the oral cavity of HIV-infected children: relation among HIV viral load, CD4+ T lymphocyte count and detection of EBV, CMV and HSV. Pesquisa Odontologica Brasileira (Brazilian Oral Research) 2005;19(3):228-34.

H.M. Rosenblatt, L.Y. Song, S.A. Nachman, K.E. Stanley, P.A. Krogstad, G.M. Johnson, A.A. Wiznia and the PACTG 377 Study Team. Tetanus immunity after diphtheria, tetanus toxoids, and acellular pertussis vaccination in children with clinically stable HIV infection. J Allergy Clin Immunol 2005;116(3):698-703.

J.R. King, S. Nachman, R. Yogev, J. Hodge, G. Aldrovandi, M.D. Hughes, J. Chen, A. Wiznia, B. Damle, E.P. Acosta. Efficacy, tolerability and pharmacokinetics of two nelfinavir-based regimens in HIV-infected children – PACTG 403. Pediatr Infect Dis J 2005; 24(10):880-885.

H.M. Rosenblatt, L.Y. Song, S.A. Nachman, K.E. Stanley, P.A. Krogstad, G.M. Johnson, and A.A. Wiznia. Tetanus immunity after diphtheria, tetanus toxoids, and acellular pertussis vaccination in children with clinically stable HIV infection. J Allergy Clin Immun 2005; 116(3):698-703.

L. Gabis, A. Belman, W. Huang, M. Milazzo, and S. Nachman. Clinical and imaging study of HIV-1 infected youth on HAART therapy – A pilot study using MR spectroscopy. Accepted J Child Neurol, July 2005.

C. Seifert, K. Reich, S. Nachman. Moving Beyond the Clinic: Nutritional Intervention in the HIV-Infected Pregnant Population. Journal of the American Dietetic Association, March 12, 2006.

M.L. Nozyce, S.S. Lee, A. Wiznia, S. Nachman, L. Mofenson, E. Smith, R. Yogev, K. McIntosh, K. Stanley, S. Pelton. A behavioral and cognitive profile of clinically stable HIV infected children receiving antiretroviral therapy. Pediatrics 2006 Mar;117(3):763-70.

Weinberg, P. Gona, S.A. Nachman, P. Defechereux, R. Yogev, W. Hughes, D. Wara, C. Elgie, M. Cooper, W. Dankner and the PACTG 1008 Team. Antibody responses to hepatitis A vaccine among HIV-infected children with evidence of immunologic reconstitution on antiretroviral therapy. J Infect Dis Jan 2006;193(2):302-11.

Ylitalo N. Brogly S. Hughes MD. Nachman S. Dankner W. Van Dyke R. Seage GR 3rd. Pediatric AIDS Clincial Trials Group Protocol 219C Team. Risk factors for opportunistic illnesses in children with human immunodeficiency virus in the era of highly active antiretroviral therapy. Archives of Pediatrics & Adolescent Medicine. 160(8):778-87, 2006 Aug.

Gona P. Van Dyke RB. Williams PL. Dankner WM. Chernoff MC. Nachman SA. Seage GR 3rd. Incidence of opportunistic and other infections in HIV-infected children in the HAART era. JAMA. 296(3):292-300, 2006 Jul 19.

K. Okonkwo, K. Reich, A. Alabi, N. Umeike, S. Nachman. An evaluation of awareness: Attitudes and beliefs of pregnant Nigerian women toward voluntary counseling and testing for HIV. Accepted by AIDS Patient Care and STDs on July 6, 2006.

Dixon, D, Goldberg, R, Schneiderman, N, & Delamater, A. (2004). Gender differences in TNF-alpha levels among obese versus non-obese Latino children. European J Clin Nutrition, (58), 696-699.

Dixon, D, Goldberg, R, Schneiderman, N, & Delamater, A. (under reivew). Body Mass Index, stressful life events and TNF-a production in children.

Dixon, D, Antoni M, Wagner S, Kilbourn K, Schneiderman N, Klimas N, Fletcher MA. (under review). Psychological distress predicts losses in perceived social support two years following a natural disaster in HIV+ gay men.

Dixon, D. (manuscript in progress). The development and psychometric evaluation of a new scale designed to assess readiness for psychotherapy as adjunctive treatment for medical illness.

W. Dankner, S. Nachman, R. Yogev, W. Hughes, P. Gona, S. Huang, C. Elgie, and the PACTG 1008 Team. An observational study of the rate of opportunistic infection (OI) events in HIV-infected children. Abstract #S-6. 11th Annual Conference on Retroviruses and Opportunistic Infections, San Francisco, California. February 2004.

Weinberg, S. Nachman, P. Gona, P. Defechereux, R. Yogev, W. Hughes, D. Wara, C. Elgie, M. Cooper, W. Dankner, and the PACTG 1008 Team. Antibody responses to hepatitis A virus vaccine (HAVV) among HIV-infected children with evidence of immunologic reconstitution. Abstract S-29. 11th Annual Conference on Retroviruses and Opportunistic Infections, San Francisco, California February 2004.

H. Rosenblatt, L.Y. Song, K. Stanley, S. Nachman, P. Krogstad, G. Johnson, A. Wiznia and the PACTG 727 Study Group. Tetanus immunity and response to DTaP booster immunization in children with stable HIV on HAART. Abstract S-90. 11th Annual Conference on Retroviruses and Opportunistic Infections, San Francisco, California February 2004.

J. Maloney, D. Djokic, S. Nachman. Influenza vaccination uptake in pediatric health care providers. Abstract 23. St. Jude/PIDS Pediatric Microbial Research Conference, Memphis, Tennessee, February 2004.

S.A. Nachman, P. Gona, R.B. Van Dyke, W.M. Dankner, P.L. Williams, G.R. Seage. Incidence of non-infectious complications in perinatally HIV-infected children and adolescents in the HAART era. 2004 Annual Meeting of IDSA. Boston, MA. September 30 – October 3, 2004.

R.B. Van Dyke, P. Gona, W.M. Dankner, S.A. Nachman, P.L. Williams, G.R. Seage. Incidence of opportunistic infections (OI&I) in HIV-infected children in the HAART era. 2004 Annual Meeting of IDSA. Boston, MA. September 30 – October 3, 2004.

S. Nachman, M. Levin, L.Y. Song, A. Weinberg, R. Walker, and the PACTG 1057 Team. Phase I/II randomized trial of the safety and immunogenicity of live attenuated influenza vaccine (LAIV) vs. inactivated influenza vaccine (TIV) in HIV-infected children. Abstract #R-106 Conference on Retroviruses and Opportunistic Infections 2006.

D. Djokic, L. Pontrelli, C.C. Ginocchio, R. Manji, F. Zhang, M. De Baar, S. Nachman. Influence Of Age, Sex And Illness On The Mitochondrial DNA Levels In HIV Uninfected Children. Accepted for poster presentation at The 24th Annual Meeting of the European Society for Paediatric Infectious Diseases, May 3-5, 2006, Basel, Switzerland.

J. Hitti, L. Frenkel, L. Stevens, S. Huang, A. Stek, S. Nachman, E. Smith, H. Watts for the PACTG 1022 Team. Comparison of venous lactate concentrations in late pregnancy and postpartum: PACTG 1022. Conference on Retroviruses and Opportunistic Infections 2006.

P. Williams, K. Gadow, M. Chernoff, P. Brouwers, S. Nachman, PACTG 1055 Team. Psychiatric co-morbidity in perinatally infected HIV-infected youth. Abstract #CDC0004. XVI International AIDS Conference, August 13-18 2006.

M. Cotton, H. Rabie, H. Weber, G. Lottering, S. Nachman. A window into health care of HIV exposed infants in a community with high prevalence of HIV and tuberculosis: Lessons from screening for a prospective clinical trial. Abstract # MOPE0269. XVI International AIDS Conference, August 13-18, 2006.

K.C. Okonkwo, S. Nachman, K. Reich. Socio-demographic determinants associated with participation in programs aimed at prevention of mother to child transmission of HIV in Nigerian women. Abstract # CDC0838. XVI International AIDS Conference, August 13-18, 2006.

K. Reich, M. Shikora, K. Thomas, M. Leger, A. Castro, S. Nachman. Attitudes towards childbearing among HIV+ youth. Poster presentation at the National Institutes of Mental Health Annual International Research Conference on the Role of Families in Preventing and Adapting to HIV/AIDS. July 19-21, 2006, San Juan, Puerto Rico.