Kenneth R. Shroyer, MD, PhD

Kenneth R. Shroyer, MD, PhD      
The Marvin Kuschner Professor
Chair of Pathology
Basic Science Tower, Level 9
Stony Brook University Medical Center
State University of New York at Stony Brook
Stony Brook, NY 11794-8691

Tel:  (631) 444-3000
Fax: (631) 444-3424
email: kenneth.shroyer@stonybrook.edu

Education:

Postdoctoral Training:

Awards and Honors:

Clinical Practice:

Dr. Shroyer is Board Certified in Anatomic and Clinical Pathology (1991), with subspecialty certification in Cytopathology (1995).  He is a general surgical pathologist with a subspecialty expertise in gynecologic oncology.  He also has extensive experience in gynecologic and non-gynecologic cytopathology, including fine needle aspiration cytopathology. He has pioneered novel methods to improve the accuracy of the cytologic and histologic classification of tumors.

Research Summary:

Dr. Shroyer is nationally known for his work related to the molecular characterization of benign, premalignant, and malignant lesions of the female genital tract. He is an authority on immunohistochemical methods and pioneered the development of techniques for mRNA in situ hybridization and the analysis of patterns of x-chromosome inactivation in archival microdissected tissues. His laboratory has also developed and evaluated the expression of a wide range of novel molecular assays of cellular immortalization and malignant transformation, including telomerase, HPV, survivin, p16, and B7-H4.  

Selected Recent Publications:
(from a total of 103 original manuscripts)

B. Tringler, W. Liu, L. Corral, K.C. Torkko, T. Enomoto, S. Davidson, M.S. Lucia, D.E. Heinz, K.R. Shroyer. B7-H4 overexpression in ovarian carcinoma. Gynecologic Oncol. 100:44-52, 2006. PDF

N.S. Spoelstra, N.G. Manning, Y. Higashi, D. Darling, M. Singh, K.R. Shroyer, R.R. Broaddus, K.B. Horwitz, J.K. Richer. The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers. Cancer Res 66: 3893-3902, 2006. PDF

T. Miyatake, T. Enomoto, Y. Ueda, K.R. Shroyer, T. Yoshizaki, H. Kanao,Y. Ueno, H. Sun, R.  Nakashima, K. Yoshino, T. Kimura, T. Haba, K. Wakasa, Y. Murata. Clonality Analysis and HPV Infection in Squamous Metaplasia and Atypical Immature Metaplasia of Uterine Cervix: Is Atypical Immature Metaplasia a Precursor to CIN 3? Int. J. Gynecol. Pathol. 26, 180-7, 2007.  Abstract

K.R. Shroyer, D. Heinz, Petra Homer, and M. Singh. Validation of a novel immunocytochemical assay for topoisomerase II alpha and minichromosome maintenance protein 2 expression in cervical cytology. Cancer Cytopathology. 108:324-30, 2006. PDF

Dehn D. K. Torkko and Shroyer K.R. Recent Progress in HPV Testing, Future Directions in Cytology. Cancer Cytopathology. 111:1-14, 2007.

T. Miyatake, B. Tringler, D.D. Dehn, A. Swisher, W. Liu, S. Lee, L. Corral, J. Papkoff, T. Enomoto, K.C. Torkko, K.R. Shroyer. B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid carcinomas and is inversely correlated with tumor T cell infiltration. Gynecologic Oncology,  106:119-27, 2007. PDF

K.C. Mugler, M. Singh, B. Tringler, J. Papkoff, W. Lui, and K.R. Shroyer. B7-H4 (DD-O110) in benign, pre-malignant and malignant lesions of the breast. Applied Immunohistochem. and Mol. Morph. 15: 263-270, 2007.

N.S. Awadallah, K.R. Shroyer, D.A. Langer, K.C. Torkko, Y.K. Chen, J.S. Bentz, J. Papkoff, W. Liu, R.J. Shah, Detection of B7-H4 (DD-O110) and p53 in pancreatic cancer: potential roles as cytologic diagnostic adjuncts, In Press, Pancreas.  Abstract

E.M. Reno, J.M. Haugian, I.K. Dimitrova, T.A. Jackson, K.R. Shroyer, A.P. Bradford. Analysis of protein kinase C delta (PKCδ) in endometrial tumors. Human Pathology. 39: 21-29 (2008).  PDF

N.S. Awadallah, D. Dehn, R.J. Shah, Y.K. Chen, D. Ross, J.S. Bentz, K.R. Shroyer. NQO1 Expression in Pancreatic Cancer and its Potential use as a Biomarker. In Press, Applied Immunohistochemistry and Molecular Morphology.  Abstract

J. Ling, U. Wiederkher, S. Cabiness, K.R. Shroyer, J Robinson. Application of flow cytometry for biomarker-based cervical cancer cells identification. In Press, Cancer Cytopathology. PDF 

E.U. Yee, R.J. Zaino, Kathleen C. Torkko, K.R. Shroyer. B7-H4 expression in Brenner tumors, a descriptive and comparative study. Histopathology. 2010 56:652-4.

P. Samarawardana, D.L. Dehn, M. Singh, D. Franquemont, C. Thompson, L. Gaido, K.C. Torkko, P. Homer, S. Burke, M.A. Titmus, V. Nayi, K.R. Shroyer. p16INK4a Is Superior to High-Risk Human Papillomavirus Testing in Cervical Cytology for the Prediction of Underlying High-Grade Dysplasia. Cancer Cytopath. 2010 (In press)  PDF

P.S. MacLean, E.D. Giles, G.C. Johnson, S.M. McDaniel, B.K. Fleming-Elder, K.A. Gilman, A.G. Andrianakos, M.R. Jackman, K.R. Shroyer, P.J. Schedin. A surprising link between the energetics of weight gain and mammary tumor progression in a model of postmenopausal obesity. Obesity, Oct 1, 2009 (in press).

Y.-K. Luu, E. Ozcivici, E.Capilla, B. Adler, E. Chan, K.R. Shroyer, J. Rubin, S. Judex, J. Pessin, C.T. Rubin. Development of Diet Induced Fatty Liver Disease in the Aging Mouse is Suppressed by Brief Daily Exposure to Low Magnitude Mechanical Signals. Int. J. Obesity. In press.

E.F. Redente, L.D. Dwyer-Nield, K. Raina, P.L. Rice, D.T. Merrick, W. Pao, J.A. Whitsett, R. Agarwal, K.R. Shroyer, A.M. Malkinson. Tumor Progression Stage and Anatomical Site Regulate Tumor-Associated Macrophage and Bone Marrow-Derived Monocyte Activation. Am J Pathol. Apr 29, 2010.