Kanokporn Rithidech, Ph.D., Associate Professor of Research Pathology.

Kanokporn Noy Rithidech, Ph.D.
Associate Professor, Pathology
Stony Brook University Medical Center
School of Medicine
Stony Brook, NY 11794-8691

Tel: (631) 444-3446
Fax: (631) 444-3424
E-mail: krithidech@notes.cc.sunysb.edu

Education:

Research Interests:

One of my longstanding interests is the identification of mechanisms involving in radiation induced acute myeloid leukemia (AML) using the CBA/Ca mouse model. It is clear that ionizing radiation can induce AML in mice and human beings. However, little is known of the molecular mechanism(s) by which radiation induces the leukemogenic phenotype. The CBA/Ca mouse AML model, once it is well characterized at the cellular and molecular levels, can help in the understanding of the stages involved in the development of AML and in radiation risk assessment in human beings.

The recent work done in my laboratory using microsatellite markers has resulted in identifying two commonly deleted regions on mouse chromosome 2 related to the induction of AML in the mouse. Our data provide the first evidence for two separate regions on mouse chromosome 2 harboring genes related to radiation induced mouse AML. Identification of such genes would have clinical significance because it would greatly improve our understanding of the pathogenesis of human AML, due to the extensive homology between mouse and human genes.

I also am investigating the induction of genomic instability by low doses of ionizing radiation in mice with different genetic backgrounds. These studies are important because genomic instability is the key event in the induction of cancer. Understanding mechanisms involved in the induction of genomic instability would have clinical applications.

Genomic assays (spectral karyotyping or mFISH, gene expression and DNA methylation profiles) are being used to characterize the early response following in vivo exposure to ionizing radiation, and to determine whether differences in response patterns are associated with subsequent expression of genomic instability or acute myeloid leukemia.

Selected Publications Within Three Years (PDFs will open in new window) :

Rithidech, K.N., W. Supanpaiboon, L. Honikel, E.B. Whorton (2009) In Vivo Induction of micronucleus in mouse blood erythrocytes following exposure to ⁵⁶Fe ions or ¹³⁷Cs rays, In Press, Adv Space Res  PDF

Rithidech, K.N., L. Honikel, R. Rieger, W. Xie, T. Fischer, S. R. Simon (2009) Protein expression profiles in mouse blood plasma following acute whole body exposure to ¹³⁷Cs rays, Int. J Radiat. Biol., 85(5):432-447, Apr 7:1-16. [Epub ahead of print]  PDF

Rithidech, K.N., Honikel, L., Milazzo, M., Madigan, D., Troxell, R., Krupp, L.B. (2009) Protein expression profiles in pediatrics multiple sclerosis: Potential biomarkers, Mult Scler., 15(4):455-464  PDF

Rithidech, K.N., M. Golightly, E.B. Whorton (2008) Analysis of cell cycle in mouse bone marrow cells following acute in vivo exposure to 56Fe ions, J Radiat Res, 49:437-443. PDF

Rithidech, K.N., B. Scott (2008) Evidence for radiation hormesis after in vitro exposure of human lymphocytes to low doses of ionizing radiation, Dose Response, 6:252-27. PDF

Rithidech, K.N., L. Honikel S.R. Simon (2007) Radiation Leukemogenesis: A proteomic approach, Exp Hematology, 35(4S)117-124. PDF

Rithidech, K.N., L. Honikel, E.B. Whorton (2007) mFISH analysis of chromosomal damage in bone marrow cells collected from CBA/CaJ mice following whole body exposure to heavy ions (56Fe ions), Radiat and Environ Biophysics, 46(2):137-45. PDF

Rithidech, K.N., W. Supanpaiboon, L. Honikel and E.B. Whorton (2007) Analysis of chromosomal damage after in vivo exposure to 56Fe ions by means of mFISH and micronucleus methods, Adv Space Res, 40:491-500.

Rithidech, K., M. Tungjai and E.B. Whorton (2005) Protective effect of Apigenin on Radiation induced chromosomal damage in human lymphocytes, Mutat Res 585(1-2):96-104.

Rithidech, K. N., M. Tungjai, E. Arbab and S.R. Simon (2005) Activation of NF-kB in bone marrow cells of BALB/cJ mice following exposure in vivo to low doses of 137Cs g rays, Radiat and Environ Biophysics, 44(2):139-143.