JIANG CHEN, MD

Jiang Chen, MD
Associate Professor
Departments of Pathology and Dermatology
Basic Science Tower, Level 9, Rm 151
Stony Brook Medicine
Stony Brook, NY 11794-8691  

Office:  (631) 444-3199
Lab:  (631) 444-6484
Fax:  (631) 444-3424
Email: jiang.chen@stonybrookmedicine.edu      

Research Summary:   
Dr. Chen’s laboratory is interested in using the skin and hair follicles as model systems to understand signaling pathways involved in epithelial development, homeostasis and cancer.  Recently, Dr. Chen’s laboratory discovered that tissue-specific PCP effector genes are essential for the formation of the primary cilium, which is indispensible for processing hedgehog (Hh) signals during follicular keratinocyte differentiation.  The main focus of Dr. Chen‘s current research is to use genetically engineered mutant mouse models to determine how PCP signaling and primary cilia regulate keratinocyte proliferation, migration, differentiation during skin development and skin cancer formation.  Knowledge gained from these studies will provide important insights into hair loss and the development of skin cancers.  Dr. Chen’s laboratory is also involved in the development of keratinocyte stem cells-based therapeutic strategies for genetic skin disorders caused by keratin mutations, such as epidermolytic hyperkeratosis (EHK) and pachyonychia congenita (PC).

Peer Reviewed Publications:

Dai D, Li L, Guevara E, Zeng H, Huebner A, Claypool D, Liu A and Chen J. Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death Differ (in press ).

Yasuda M, Claypool DJ, Guevara E, Roop DR and Chen J (2012). Genetic manipulation of keratinocyte stem cells with lentiviral vectors. Methods Mol Biol (in press)

Chen J and Roop DR (2012). Mimicking hair disorders by genetic manipulation of organ cultured human hair follicles. J Investig Dermatol 132:2312-4.

Li Li, Zeng Y, Fang K, Xiao Y, Jin H, Ray H and Chen J (2012). Anetodermic pilomatricoma: Molecular characteristics and trauma in the development of its bullous appearance. Am J Dermatopathol 34:e41-5.

Chen J and Chuong CM (2012). Patterning skin by planar cell polarity: the multi-talented hair designer. Exp Dermatol 21:81-5.

Bu W, Chen J, Morrison GD, Huang S, Creighton CJ, Huang J, Chamness GC, Roop DR, Leavitt AD and Li Y (2011). Keratin 6 marks bipotential mammary progenitor cells that can give rise to unique tumors resembling human normal-like breast cancer. Oncogene 30:4399-409.

Bilousova G, Chen J and  Roop DR (2011). Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage. J Investig Dermatol 131:857-64 (Cover story with commentary).

Dai D, Zhu H, Wlodarczyk B, Zhang L, Li AG, Finnell RH, Roop DR and Chen J (2011). Fuz is a PCP effector gene that controls the morphogenesis and differentiation of hair follicles.  J Investig Dermatol. 131:302-10.

Li F, Huang Q, Chen J, Peng Y, Roop DR, Bedford JS, Li CY (2010). Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration. Sci Signal. 23:ra13 (Cover story).

Chen J, Roop DR (2008). Genetically engineered mouse models for skin research: taking the next step. J Dermatol Sci. 52:1-12 (Review).

Chen J, Jaeger K, Den Z, Koch PJ, Sundberg JP and Roop DR (2008). Mice expressing a mutant Krt75 (K6hf) allele develope hair and nail defects resembling pachyonychia congenita. J Investig Dermatol. 128:270-9 (Cover story).

Chen J, Roop DR (2005) Mouse models in preclinical studies for pachyonychia congenita. J Investig Dermatol Symp Proc. 10:37-46 (Review).

Chen J, Kasper M, Heck T, Nakagawa K, Humpert PM, Bai L, Wu G, Zhang Y, Luther T, Andrassy M, Schiekofer S, Hamann A, Morcos M, Chen B, Stern DM, Nawroth PP, Bierhaus A (2005). Tissue factor as a link between wounding and tissue repair. Diabetes. 54:2143-54. 

Chen J, Bierhaus A, Schiekofer S, Andrassy M, Chen B, Stern D, Nawroth P (2001). Tissue factor--a receptor involved in the control of cellular properties, including angiogenesis. Thromb Haemost. 86:334-45 (Review).

Abe K, Shoji M, Chen J, Bierhaus A, Danave I, Micko C, Casper K, Dillehay D, Nawroth P, Rickles F (1999). Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor. Proc Natl Acad Sci U S A. 96:8663-8.

Zhang Y, Weiler-Guettler H, Chen J, Wilhelm O, Deng Y, Qiu F, Nakagawa K, Klevesath M, Wilhelm S, Bohrer H, Nakagawa M, Graeff H, Martin E, Stern D, Rosenberg R, Ziegler R, Nawroth P (1998). Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity. J Clin Invest. 101:1301-9.