Research Interests

Lab Members:
Lisa Ballou (Research Assistant Professor), Ya-Ping Jiang (Research Scientist), Elzbieta Selinger (Research Support Specialist), Chia-Yen Wu (Ph.D. Student), Mohar Chattopadhy (Ph.D. Student), Jun Yong Choi (Ph.D. Student), Justin Tsai (M.S. Student)

My laboratory's investigation concerns the intracellular signaling molecules that regulate cell growth. The focus our studies has been on phosphatidylinositol (PI) 3-kinase that produces the lipid second messenger, PI(3,4,5)P3. Dysregulation of the PI 3-kinase signaling pathway is involved in the development of cancer and diabetes mellitus. Currently, we are using biochemical and molecular techniques to investigate how the various PI 3-kinase isoforms are regulated. We are also using genetically modified mice to investigate the physiological consequences of PI 3-kinase down regulation.