Hoang-Lan Nguyen, Ph.D.

Hoang-Lan Nguyen, Ph.D.
Research Scientist
e-mail: Hoang-Lan.Nguyen@stonybrook.edu

Dr. Nguyen received a Ph.D. from Columbia University in the laboratory of Dr. J. Chloe Bulinsky, where she focused on characterizing the in vivo functions of a microtubule-associated protein, MAP4, in cultured cells.   Dr. Nguyen's post-doctoral work was with Dr. Sidney Strickland at Stony Brook, studying the plasmin/fibrin pathway in spinal cord injury and in Type II diabetes.

Dr. Nguyen was subsequently Senior Scientist at Cornerstone Pharmaceuticals, where she played key roles in developing two new drugs, which have been FDA approved, for testing in human clinical trials.

Dr. Nguyen is currently studying the cancer cell metastasis and the roles played by MMP14 and Wnt-5a in metastasis.

Publications:

  1. Nguyen HL, Gruber D, and Bulinski JC. MAP4 regulates microtubule assembly, protomerpolymer partitioning, and tubulin synthesis. J. Cell Sci. 112:1813-1824, 1999
  2. Nguyen HL, Gruber D, McGraw T, Sheetz MP, and Bulinski JC. Stabilization and functional modulation of microtubules by microtubule-associated protein 4. Biological Bulletin 194:354-357, 1998.
  3. Bulinski  JC, McGraw  TE, Gruber D, Nguyen HL, and Sheetz MP. Overexpression of MAP4 inhibits organelle motility in vivo. J. Cell Sci. 110: 3055-3064, 1997.
  4. Nguyen HL, Chari S, Gruber D, Lue C-M, Chapin SJ, and Bulinski JC. Overexpression of full or partial-length MAP4 stabilizes microtubules and alters cell growth. J. Cell Sci. 110:281-294, 1997.
  5. Tycko B, Feng L, Nguyen HL, Francis, A, Hays, A, Chung, W-Y, Tang, M-X, Stern, Y, Sahota, A, Hendrie, H, and Mayeux, R. Polymorphism in the human apoliprotein-J/clusteriln gene: Ethnic variation and distribution in Alzheimer's Disease. Hum. Genet. 98:430-436, 1996.
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