Gerardo Mackenzie, Ph.D.

 

Gerardo Mackenzie, Ph.D. 
Research Scientist

Research Instructor of Medicine
e-mail: Gerardo.Mackenzie@stonybrookmedicine.edu

Dr. Mackenzie received his Ph.D. from the University of Buenos Aires, Argentina and did postdoctoral work at the University of California, Davis prior to joining the Division of Cancer Prevention at Stony Brook. Previously, he was involved in two primary areas of research. The first was centered on the characterization of the effects of zinc deficiency on early developmental processes; and the second area of research was focused on the beneficial effects of plant-derived polyphenolic compounds against certain cancers. Currently, he is evaluating novel targets and mechanism-based pharmacological agents for the management of colon and pancreatic cancer, having achieved remarkable anticancer efficacies in preliminary studies.

Selected Publications:

  1. Mackenzie, G.G., Sun, Y, Huang, L, Xie, G, Ouyang, N, Gupta, RC, Johnson F, Komninou, D, Kopelovich, L and Rigas, B. The novel agent phospho-sulindac (OXT-328) is a safe and effective agent for colon cancer prevention in mice. Gastroenterology, 139(4):1320-32 (2010).  To view pdf click here

  2. Hua, A.*, Mackenzie, G.G.*, and Rigas, B. The differential cell signaling effects of two positional isomers of the anticancer NO-donating aspirin (International Journal of Oncology; 35(4):837-44 (2009). *Equally contributed to this manuscript.  To view pdf click here

  3. Zhao, W., Mackenzie, G.G., Murray, O.T., Zhang, Z. and Rigas, B. Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: A redox-dependent effect. Carcinogenesis; 30(3):512-9 (2009).  To view pdf click here

  4. Mackenzie GG, Queisser N, Wolfson M, Fraga CG, Adamo AM, Oteiza PI.   Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutive active NF-κB and STAT3 pathways in Hodgkin’s lymphoma. International J. Cancer 123(1):56-65. (2008).  To view pdf click here

  5. Mackenzie GG, Adamo AM, Decker NP, Oteiza, PI.  Dimeric procyanidin B2 inhibits constitutively active NF-κB-dependent gene expression in Hodgkin'slymphoma cells.  Biochemical Pharmacology 75:1461-1471 (2008). To view pdf click here

  6. Mackenzie GG, Oteiza, PI  Zinc and the cytoskeleton in the neuronal modulation of transcription factor NFAT. Journal of Cellular Physiology 210 (1):24-256 (2007).   To view pdf click here

  7. Mackenzie GG, Keen CL, Oteiza PI. Microtubules are required for NF-κB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc.  Journal of Neurochemistry 99(2): 402-415 (2006).  To view pdf click here

  8. Zago MP, Mackenzie GG, Adamo AM, Keen CL, Oteiza PI.  Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: role of H2O2. Antitioxid Redox Signal. 7(11-12):1773-82 (2005).   To view pdf click here

  9. Oteiza PI, Mackenzie GG.  Zinc, oxidant -triggerred cell signaling and human health.  Molecular Aspects of Medicine 26(4-5):245-255 (2005).  To view pdf click here

  10. Mackenzie GG,Carrasqueo F, Delfino JM, Keen CL, Fraga CG, Oteiza, PI. Epicatechin, catechin and dimeric procyanidins inhibit PMA-induced NF-κB activation at multiple steps in Jurkat T cells.  FASEB Journal 18: 167-169 (2004).   To view pdf click here

  11. Verstraeten SV, Zago MP, Mackenzie GG, Keen C L, Oteiza PI.  Influence of  zinc deficiency on cell membrane fluidity in Jurkat T, 3T3 and IMR-32 cells. Biochemical Journal 378:579-587 (2004). To view pdf click here

  12. Mackenzie GG, Zago MP, Keen CL, Oteiza PI. Low intracellular zinc impairs the translocation of activated NF-κB to the nuclei in human neuroblastoma IMR-32 cells.  Journal of Biological Chemistry 277:34610-34617 (2002). To view pdf click here
AttachmentSize
JBC2002.pdf344.46 KB
NONINEBiochemJ2004.pdf247 KB
FASEB2004.pdf1.01 MB
MolAspofMedReview2005.pdf137.8 KB
NOSIXZn-MAPKAntioxandRedoxsignals2005.pdf194.22 KB
NOFIVEJneurochemistry2006.pdf516.6 KB
NOFOUR2007Zn-NFATJcellPhysiology.pdf433.63 KB
2008BiochemPharm.Macetal.pdf1.28 MB
NoTwo2008CurcuminHodgkin.pdf1.2 MB
Gastroenterology OXT-328.pdf1.5 MB
Int J Oncol Isomers 2009.pdf429.3 KB
Phospho-aspirin Carcinogenesis 2009.pdf789 KB
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